Lyst protein complexes and lyst interacting proteins

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2325562

The present invention relates to complexes of the LYST or LYST-2 protein with proteins identified as interacting with LYST or LYST-2 by a modified yeast two hybrid assay system. The proteins identified to interact with LYST or LYST-2 are 14-3-3 protein, HS1 protein, Hrs, BMK1, KB07, Efs, XAP-4, OS9, casein kinase II beta SU, calmodulin, troponin I, importin beta, Fte-1, hERR1, imogen 38, atrophin-1, norbin, HBF-G2, DGS-I, GBDR1, OPA containing protein, M4 protein, LIP1, LIP2, LIP3, LIP4, LIP5, LIP6, LIP7, LIP8, LIP9 and LIP10. Thus, the invention provides complexes of LYST or LYST-2 and 14-3-3 protein, HS1 protein, Hrs, BMK1, KB07, Efs, XAP-4, OS9, casein kinase II beta SU, calmodulin, troponin I, importin beta, Fte-1, hERR1, imogen 38, atrophin-1, norbin, HBF-G2, DGS-I, GBDR1, OPA containing protein, M4 protein, LIP1, LIP2, LIP3, LIP4, LIP5, LIP6, LIP7, LIP8, LIP9 and LIP10, and derivatives, fragments and analogs thereof. The invention also provides nucleic acis encoding the LIP1, LIP2, LIP3, LIP4, LIP5, LIP6, LIP7, LIP8, LIP9, and LIP10 protein, or derivatives, fragments and analogs thereof. Methods of screening the complexes or proteins for efficacy in treating and/or preventing certain diseases and disorders, particularly atopic diseases, autoimmune diseases, neurodegenerative disease, cancer, pigmentation disorders, platelet dysfunction and viral diseases, are also provided.

La présente invention concerne des complexes de la protéine LYST ou LYST-2, les protéines étant identifiées pour leur interaction avec LYST ou LYST-2 par un système d'analyse hybride à la levure. Les protéines interagissant avec LYST ou LYST-2 sont les protéines 14-3-3, HS1, Hrs, BMK1, KB07, Efs, XAP-4, OS9, caséine-kinase II bêta SU, calmoduline, troponine I, importine bêta, Fte-1, HERR1, imogène 38, atrophine-1, norbine, HBF-G2, DGS-I, GBDR1, la protéine contenant OPA, la protéine M4, LIP1, LIP2, LIP3, LIP4, LIP5, LIP6, LIP7, LIP8, LIP9, et LIP10. L'invention concerne donc des complexes de LYST ou LYST-2 et des protéines 14-3-3, la prétine HS1, Hrs, BMK1, KB07, Efs, XAP-4, OS9, caséine-kinase II bêta SU, calmoduline, troponine I, importine bêta, Fte-1, HERR1, imogène 38, atrophine-1, norbine, HBF-G2, DGS-I, GBDR1, la protéine contenant OPA, la protéine M4, LIP1, LIP2, LIP3, LIP4, LIP5, LIP6, LIP7, LIP8, LIP9, et LIP10, ainsi que des dérivés, des fragments, et des analogues de ceux-ci. Cette invention concerne également des acides nucléiques codant pour les protéines LIP1, LIP2, LIP3, LIP4, LIP5, LIP6, LIP7, LIP8, LIP9, et LIP10, ainsi que des dérivés, des fragments, et des analogues de ceux-ci. L'invention concerne en outre des méthodes de criblage de ces complexes ou de ces protéines, ces méthodes permettant de déterminer l'efficacité de ces complexes ou de ces protéines pour prévenir et/ou traiter certaines maladies et certains troubles, en particulier les maladies atopiques, les maladies auto-immunes, les maladies neurodégénératives, le cancer, les troubles de la pigmentation, les dysfonctionnements plaquettaires, et les maladies virales.

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