M-csf monoclonal antibodies that recognize a neutralizing...

Details M-csf monoclonal antibodies that recognize a neutralizing... M-csf monoclonal antibodies that recognize a neutralizing...

C - Chemistry, Metallurgy

12

P

167/37, 195/1.10

C12P 21/08 (2006.01) C07K 1/22 (2006.01) C07K 14/53 (2006.01) C07K 16/24 (2006.01) C12N 15/02 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2008817

Monoclonal antibodies are described, and methods of using the same, that bind to an apparent conformational epitope associated with recombinant or native dimeric M-CSF with concomitant neutralization of biological activity, which monoclonal antibodies are substantially unreactive with biologically inactive forms of M- CSF including monomeric and chemically derivatized dimeric M-CSF.

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