A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 29/00 (2006.01) A61K 31/65 (2006.01) A61L 27/00 (2006.01) A61L 29/08 (2006.01) A61L 29/16 (2006.01)
Patent
CA 2148942
Disclosed are pharmaceutical compositions of a mixture of minocycline and EDTA (M-EDTA) and methods of using the compositions in maintaining the patency of a catheter port. Methods for inhibiting the formation of polysaccharide-rich glycocalyx (such as the glycocalyx of staphylococcal organisms) are also provided using an M-EDTA solution. A solution including minocycline, EDTA or both, may also be used to pretreat a medical device to prevent adherence of infectious organisms, such as S. epidermidis and S. aureus. The compositions destroy and prevent the formation of polysaccharide-rich glycocalyx. Methods for treating infections of S. epidermidis and S. aureus where glycocalyx formation are provided with an M-EDTA solution. The minocycline and EDTA solutions are included together within a pharmacologically acceptable carrier solution, such as saline.
Raad Issam
Sherertz Robert J.
Bereskin & Parr
Board Of Regents The University Of Texas System
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