M-protein peptides of influenza virus as antiviral agents

Details M-protein peptides of influenza virus as antiviral agents M-protein peptides of influenza virus as antiviral agents

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 9/127 (2006.01) A61K 38/10 (2006.01) A61K 38/55 (2006.01) C07K 14/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2108263

2108263 9222575 PCTABS00018 Peptides substantially corresponding to the 148-162 region of type A influenza M protein and additionally containing at least one amino acid in the 163-166 region are disclosed to have high activity as influenza transcription inhibitors and thus as antiviral agents against influenza virus and other RNA viruses. The modification of these peptides by incorporation into liposomes or by addition of long-chain alkylamino acids is also shown as in the use of all such materials in antiviral drug formulations.

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