M1 and/or m3 receptor antagonists in combination with other...

Details M1 and/or m3 receptor antagonists in combination with other... M1 and/or m3 receptor antagonists in combination with other...

A - Human Necessities

61

K

A61K 31/4545 (2006.01) A61K 31/216 (2006.01) A61P 11/02 (2006.01) A61P 11/06 (2006.01) A61P 11/14 (2006.01)

Patent

CA 2585122

The present invention relates to formulations useful for treating respiratory disorders associated with the production of mucus glycoprotein, skin disorders, and allergic conjunctivitis while substantially reducing adverse effects associated with the administration of non-selective anti-cholinergic agents and methods of use thereof. In particular, the formulations include a selective muscarinic acetylcholdine receptor subtype M1 and/or M3 antagonist such as oxybutynin in combination with one or more pharmaceutically active agents, such as desloratidine.

Cette invention concerne des formulations utiles à la fois pour le traitement de maladies respiratoires associées à la production de glycoprotéine du mucus, aux maladies de la peau et à la conjonctivite allergique et pour la réduction considérable des effets indésirables associés à l'administration d'agents anticholinergiques non sélectifs. L'invention concerne également les procédés d'utilisation de ces formulations. En particulier, les formulations incluent un antagoniste des récepteurs muscariniques de l'acétylcholine sélectifs, de sous-type M1 et/ou M3, tel que l'oxybutynine combinée à un ou plusieurs agents actifs pharmaceutiquement, tel que la desloratidine.

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