Macrocycles useful in the treatment of alzheimer's disease

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 498/08 (2006.01) A61K 31/395 (2006.01) A61K 31/404 (2006.01) A61K 31/422 (2006.01) A61K 31/4427 (2006.01) A61P 25/28 (2006.01) C07D 273/02 (2006.01) C07D 291/08 (2006.01) C07D 413/04 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 419/12 (2006.01)

Patent

CA 2450167

The present invention is macrocycles of the formula (X): for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme for the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

L'invention concerne des macrocycles de formule (X): destinés au traitement de la maladie d'Alzheimer et d'autres maladies semblables. Ces composés comprennent des inhibiteurs d'enzyme bêta-secrétase pour le traitement de la maladie d'Alzheimer et d'autres maladies caractérisées par le dépôt de peptide A bêta chez un mammifère. Les composés de l'invention sont utiles dans des compositions pharmaceutiques et dans des méthodes de traitement permettant de réduire la formation de peptide A bêta.

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