C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/12 (2006.01) A61K 31/4427 (2006.01) A61P 25/28 (2006.01) C07D 273/02 (2006.01) C07D 413/04 (2006.01)
Patent
CA 2450202
The present invention are macrocycles of the formula (IX), for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
L'invention concerne des macrocycles de la formule (IX) suivante destinés au traitement de la maladie d'Alzheimer et d'autres maladies similaires. Ces composés comprennent des inhibiteurs de l'enzyme beta-sécrétase utilisés dans le traitement de la maladie d'Alzheimer et d'autres maladies se caractérisant par le dépôt du peptide beta A chez un mammifère. Les composés selon l'invention sont utilisés dans des compositions pharmaceutiques et des procédés de traitement permettant de réduire la formation du peptide beta A.
Beck James P.
Pulley Shon R.
Tenbrink Ruth E.
Elan Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
Pharmacia & Upjohn Company
Pharmacia & Upjohn Company Llc
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