C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/08 (2006.01) A61K 31/439 (2006.01) A61P 25/28 (2006.01) C07D 491/08 (2006.01)
Patent
CA 2587256
The present invention is directed to macrocyclic aminopyridyl compounds represented by general formula (I), which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta- secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
L'invention concerne des composés d'aminopyridyle macrocyclique représentés par la formule (I) qui sont des inhibiteurs de l'enzyme bêta-secrétase et qui sont utilisés pour traiter des maladies impliquant l'enzyme bêta-secrétase, telles que la maladie d'Alzheimer. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés, et l'utilisation de ces composés et de ces compositions pour traiter des maladies impliquant l'enzyme bêta-secrétase.
Moore Keith P.
Nantermet Philippe G.
Rajapakse Hemaka A.
Selnick Harold G.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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