Macrocyclic analogs for the treatment of immunoregulatory...

Details Macrocyclic analogs for the treatment of immunoregulatory... Macrocyclic analogs for the treatment of immunoregulatory...

C - Chemistry, Metallurgy

07

D

C07D 498/18 (2006.01) A61K 31/436 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2601380

Disclosed are compounds of the Formula (I) and diastereomers, tautomers, solvates, metabolites, and pharmaceutically acceptable salts thereof, wherein X, A, L and Y are as defined herein. Such compounds are useful in the treatment of immunoregulatory and respiratory diseases in mammals. Also disclosed are methods of using such compounds in the treatment of immunoregulatory and respiratory diseases in mammals and pharmaceutical compositions containing such compounds.

La présente invention concerne des composés représentés par la formule (I) et les diastéréomères, les tautomères, les solvates, les métabolites et les sels pharmaceutiquement acceptables de ces derniers; dans la formule, X, A, L et Y étant tels que définis dans le descriptif. Ces composés sont utiles dans le traitement des maladies liées à l'immunorégulation et des maladies respiratoires. Cette invention se rapporte également à des méthodes d'utilisation de ces composés dans le traitement des maladies liées à l'immunorégulation et des maladies respiratoires chez les mammifères et des compositions pharmaceutiques contenant de tels composés.Formule (I)

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