Macrocyclic carbamate immunomodulators

Details Macrocyclic carbamate immunomodulators Macrocyclic carbamate immunomodulators

C - Chemistry, Metallurgy

07

H

C07H 19/01 (2006.01) A61K 31/70 (2006.01) C07D 498/18 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2156068

Immunomodulatory macrocyclic compounds having formula (I) and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein R8 and R9 are selected such that one of R3 and R9 is hydrogen, and the other is chosen from the group consisting of: (1) -OC(=NR10)NHR10; (2) -OC(=O)R11; and (3) -OC(=O)NR12R13, (4) -OC(=O)N(OR14)R12; (5) -OC(=O)- NHNR12R13; (6) -OC(=O)-NH-NHC(=O)-NR12R13; (7) -OC(=O)NH-NHS(O)2-NR12R13; and (8) -OC(=O)NH-NHC(=NR21)-NR12R13 as well as pharmaceutical compositions containing such compounds and methods for their use in immunosuppressive, antimicrobial, antifungal, antiviral, antiinflammatory and antiproliferative therapy.

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