Macrocyclic chelants, their chelates and uses thereof in the...

Details Macrocyclic chelants, their chelates and uses thereof in the... Macrocyclic chelants, their chelates and uses thereof in the...

C - Chemistry, Metallurgy

07

D

C07D 257/02 (2006.01) A61K 49/00 (2006.01) A61K 49/06 (2006.01)

Patent

CA 2196041

Compounds able to chelate paramagnetic bi- or trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging (MRI), of general formula (I) wherein A is a group of formula (a), wherein X is a -O-R group or is a -NR2R3 group, B1, B2, B3 can be same or different and have the same meaning as A, or are a -CHYCOX group, wherein Y is a -CH2OR1 group.

On décrit des composés capables de chélater des ions métalliques paramagnétiques bi- ou trivalents, leur chélates avec ces ions métalliques, et leurs utilisations comme agents de contraste en imagerie par résonance magnétique. Ils correspondent à la formule générale (I), où A représente un groupe de formule (a) où X représente un groupe -O-R ou -NR¿2?R¿3?; et B¿1?, B¿2? et B¿3?, identiques ou différents, ont la même notation que A ou représentent un groupe -CHYCOX où Y représente un groupe -CH¿2?OR¿1?.

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