C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/119, 260/19,
C12N 9/96 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/04 (2006.01) A61K 51/08 (2006.01) A61K 51/10 (2006.01) C07D 257/02 (2006.01) C07D 257/04 (2006.01) C07F 5/00 (2006.01) C07K 1/13 (2006.01) C07K 16/00 (2006.01) G01N 33/534 (2006.01)
Patent
CA 1339015
The invention is a chelate having a general formula Image wherein R1-4 is -CH2COOH; n is 1 to 5; X is a member selected from the group consisting of -N02, -NH2, -NCS, -NHCOCH2 - Z with Z being a member selected from the group consisting of Br and I; -COOH; and -OCH200CH; and M is a metal ion being a member selected from the group of elements consisting of Bi, Pb, Y, Cd, Hg, Al, Th, Sr, and Lanthanides. The invention can include a chelate wherein M is a copper ion and n is an integer from 2 to 5. The invention includes chelate conjugates of formula I and ligand conjugates of formula II: Image The invention also includes the use these compounds for treatment of cellular disorders and for diagnostic tests.
600714
Brechbiel Martin W.
Gansow Otto A.
Magerstadt Michael A.
Borden Ladner Gervais Llp
Brechbiel Martin W.
Gansow Otto A.
Magerstadt Michael A.
U.s. Departm Ent Of Commerce The United States Of America Represented By The Secretary
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