C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
167/37, 167/46,
C07F 5/00 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 49/06 (2006.01) C07D 471/18 (2006.01) C07D 491/18 (2006.01) C07D 495/18 (2006.01) G01N 33/53 (2006.01) G01N 33/58 (2006.01)
Patent
CA 1340527
Functionalized water soluble macrocyclic complexes of lanthanide, actinide and yttrium ions were obtained by metal templated, Schiff-base, cyclic condensation of: (1) a functionalized 1,2-diaminoethane and a dicarbonyl compound selected from the group consisting of 2,6-dicarbonylpyridine, 2,6-diformylpyridine, 2,5-dicarbonylfuran, 2,5-diformylfuran, 2,5-dicarbonyl-thiophene and 2,5-diformylthiophene; or (2) 1,2-diaminoethane and a ring-substituted heterocyclic dicarbonyl compound selected from a group consisting of substituted 2,6-dicarbonylpyridine, substituted 2,6-diformylpyridine, substituted 2,5-dicarbonylfuran, substituted 2,5-diformylfuran; substituted 2,5-dicarbonyl thiophene, and substituted 2,5-diformylthiophene. Coordination complexes thus formed are kinetically stable in dilute aqueous solution. They are further reacted, or coupled, through a substituent on the 1,2-diaminoethane or on the pyridine, furan, or thiophene moieties, to one of the following: proteinaceous materials, polysaccharides, other biologically compatible macromolecules or bridging molecules which, can be further reacted or coupled to the above mentioned substrates. These macrocyclic complexes are suitable in the preparation of reporter molecules and for magnetic resonance, radiation imaging and radiation therapy.
601002
Leif Robert C.
Vallarino Lidia
Borden Ladner Gervais Llp
Leif Robert C.
Vallarino Lidia
LandOfFree
Macrocyclic complexes of yttrium, the lanthanides and the... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Macrocyclic complexes of yttrium, the lanthanides and the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Macrocyclic complexes of yttrium, the lanthanides and the... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1336470