C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 497/08 (2006.01) A61K 31/529 (2006.01) A61K 31/53 (2006.01) A61K 31/5377 (2006.01) A61P 1/16 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 17/02 (2006.01) A61P 19/02 (2006.01) A61P 21/00 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 37/02 (2006.01) A61P 37/06 (2006.01) A61P 43/00 (2006.01) C07D 513/08 (2006.01) C07D 513/18 (2006.01) C07D 513/20 (2006.01) C07
Patent
CA 2679126
Disclosed is a new class of compound which has HSP90 inhibitory activity and is useful as an antitumor agent or the like. Also disclosed is a compound which is useful as a synthesis intermediate for the compound having HSP90 inhibitory activity. Specifically disclosed is a compound represented by the general formula (1) below, or a pharmaceutically acceptable salt thereof. (In the formula, X, R1, R2, R3, R4, R5, R6, R7, L1, L2 and L3 are as defined in the description.)
La présence invention concerne une nouvelle classe de composé qui possède une activité inhibitrice de la Hsp90 et qui est utile en tant qu'agent antitumoral ou analogues. Cette invention concerne également un composé qui est utile en tant qu'intermédiaire de synthèse pour le composé possédant une activité inhibitrice de la Hsp90. Cette invention concerne, de manière spécifique, un composé représenté par la formule générale (1) ci-dessous, ou l'un de ses sels acceptables sur le plan pharmaceutique. (Dans la formule, X, R1, R2, R3, R4, R5, R6, R7, L1, L2 et L3 sont tels que définis dans la description.)
Hada Kihito
Hasegawa Kiyoshi
Hayase Tadakatsu
Kawasaki Ken-Ichi
Kohchi Masami
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Chugai Seiyaku Kabushiki Kaisha
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