Macrocyclic compounds and their use as kinase inhibitors

Details Macrocyclic compounds and their use as kinase inhibitors Macrocyclic compounds and their use as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 239/48 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2722326

The present invention relates to macrocyclic compounds of Formula I: or pharmaceutically acceptable salts thereof or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are JAK/ ALK inhibitors useful in the treatment of JAK/ALK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.

Cette invention concerne des composés macrocycliques de Formule I : ou des sels pharmaceutiquement acceptables de ceux-ci ou des sels d'ammonium quaternaire de ceux-ci dont les éléments constitutifs sont ici fournis, ainsi que des compositions les contenant et des procédés d'utilisation, qui sont des inhibiteurs JAK/ALK utiles dans le traitement des maladies associées aux JAK/ALK comprenant, par exemple, les troubles inflammatoires et auto-immuns, ainsi que le cancer.

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