C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/08 (2006.01) A61K 31/407 (2006.01) A61K 31/439 (2006.01) A61K 31/4748 (2006.01) A61P 31/14 (2006.01) C07D 487/08 (2006.01)
Patent
CA 2761650
The present invention discloses compounds of formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
La présente invention concerne des composés de formule I ou leurs sels, esters ou promédicaments pharmaceutiquement acceptables, qui inhibent l'activité sérine protéasique, particulièrement l'activité de la protéase NS3-NS4A du virus de l'hépatite C (VHC). Par conséquent, les composés de la présente invention interfèrent avec le cycle de vie du virus de l'hépatite C et sont également utiles comme agents antiviraux. La présente invention concerne également des compositions pharmaceutiques comprenant les composés susmentionnés pour administration à un patient souffrant d'une infection par VHC. L'invention concerne également des procédés de traitement d'une infection par VHC chez un patient par administration d'une composition pharmaceutique comprenant les composés de la présente invention.
Gai Yonghua
Or Yat Sun
Wang Guoqiang
Enanta Pharmaceuticals Inc.
Gowling Lafleur Henderson Llp
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