C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 257/02 (2006.01) A61K 31/395 (2006.01) A61P 19/02 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) C07D 273/00 (2006.01)
Patent
CA 2733790
The invention provides macrocyclic compounds of formula (I) and methods for their synthesis and use. In particular, the invention provides macrocyclic compounds that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.
La présente invention concerne des composés macrocycliques ainsi que leurs procédés de synthèse et méthodes dutilisation. En particulier, linvention porte sur des composés macrocycliques qui modulent lactivité du facteur de nécrose tumorale alpha et/ou sont utiles pour le traitement détats pathologiques, tels que la polyarthrite rhumatoïde, le psoriasis et lasthme.
Bond Julian F.
Briggs Timothy F.
Favaloro Frank G.
Hale Stephen P.
Lee Jinbo
Ensemble Discovery Corporation
Ensemble Therapeutics Corporation
Smart & Biggar
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