Macrocyclic compounds made from suboxide units

Details Macrocyclic compounds made from suboxide units Macrocyclic compounds made from suboxide units

C - Chemistry, Metallurgy

07

D

C07D 493/22 (2006.01) A61K 31/35 (2006.01) A61K 31/366 (2006.01) A61K 33/00 (2006.01) A61K 47/22 (2006.01) C12P 17/18 (2006.01) G01N 33/53 (2006.01) G01N 33/564 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2241870

Bioregulatory active substances with macrocyclic structural frame which is synthesized from carbon suboxide by cyclooligomerization and additional formation of macroring structures are specified. These active substances are used as such and/or as stable adducts with other known substances. The characterization of these active substances are described as well as their organic and inorganic derivatives, methods for their synthetic production, their isolation and purification. The application of these active substances for enzyme regulation and bioregulation, medicinal compositions containing these active substances as well as their use in diagnostics and therapy is also described.

L'invention concerne des substances actives de régulation biologique présentant un squelette macrocyclique obtenu par synthèse depuis un sous-oxyde de carbone par oligomérisation cyclique et constitution supplémentaire de structures possédant des macro-noyaux. On utilise ces substances actives en tant que telles et/ou en tant que produits d'apport stable avec d'autres substances connues. L'invention décrit la caractérisation de ces substances actives, ainsi que leurs dérivés organiques et inorganiques, des procédés servant à les préparer par synthèse, à les isoler et à les purifier. Elle concerne également l'application de ces substances actives dans le but d'effectuer une régulation enzymatique et biologique, des compositions médicinales contenant ces substances actives, ainsi que leur utilisation diagnostique et thérapeutique.

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