Macrocyclic compounds useful as pharmaceuticals

Details Macrocyclic compounds useful as pharmaceuticals Macrocyclic compounds useful as pharmaceuticals

C - Chemistry, Metallurgy

07

D

C07D 313/00 (2006.01) A61K 31/335 (2006.01) A61K 31/36 (2006.01) A61K 31/395 (2006.01) A61P 11/06 (2006.01) A61P 17/06 (2006.01) A61P 17/16 (2006.01) A61P 19/04 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) C07D 225/06 (2006.01) C07D 267/00 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 491/04 (2006.01) C07D 493/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2478065

The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1 -R11, t, X, Y, Z, and n are as defined herein.

la présente invention concerne des composés représentés par la formule (I), ainsi que des méthodes de synthèse de ces composés, convenant pour le traitement de diverses pathologies dont des troubles inflammatoires et auto-immuns et des troubles à caractère malin ou impliquant une angiogenèse. Dans cette formule, R¿1? -R¿11?, t, X, Y, Z, et n sont comme définis dans le descriptif de l'invention.

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