C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 245/02 (2006.01) A61K 31/4709 (2006.01) A61P 7/00 (2006.01) C07D 255/02 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2634794
The present invention relates generally to novel macrocycles of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, thereof, wherein the variables A, B, L, M, W, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein. These compounds are selective inhibitors of the serine protease coagulation factor VIIa which can be used as medicaments.
La présente invention concerne de manière générale de nouveaux macrocycles de formule (I) : ou des stéréoisomères, des tautomères, des sels pharmaceutiquement acceptables, des solvates de ces composés, les variables A, B, L, M, W, Z, R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP>, R<SUP>6</SUP>, R<SUP>7</SUP>, R<SUP>8</SUP>, R<SUP>9</SUP> et R<SUP>10</SUP> étant définies dans le présent document. Ces composés constituent des inhibiteurs sélectifs du facteur de coagulation de sérine protéase VIIa pouvant être utilisés en tant que médicaments.
Cheney Daniel L.
Glunz Peter W.
Priestley E. Scott
Wurtz Nicholas R.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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