C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 255/04 (2006.01) A61K 31/395 (2006.01) A61P 7/02 (2006.01) C07D 271/12 (2006.01)
Patent
CA 2673598
The present invention relates generally to novel macrocycles of Formula (I) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, B, C, D, L, M, W, Z1, Z2, Z3, Z4, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.
La présente invention concerne de nouveaux macrocycles représentés par la formule (I) ou des stéréoisomères, des tautomères, des sels, des solvates ou des précurseurs de médicament pharmaceutiquement acceptables de ces derniers, dans lesquels les variables A, B, C, D, L, M, W, Z1, Z2, Z3, Z4, R1, R2, R3, R4, R5, R6, R7, R8, R9et R10 sont telles que définies dans le descriptif. Ces composés sont des inhibiteurs sélectifs du facteur VIIa qui peuvent être utilisés en tant que médicaments.
Cheney Daniel L.
Glunz Peter W.
Ladziata Vladimir
Mueller Luciano
Parkhurst Brandon
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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