Macrocyclic hepatitis c protease inhibitors

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/12 (2006.01) C07K 5/12 (2006.01) C07K 7/50 (2006.01)

Patent

CA 2679563

The present invention provides novel macrocyclic compounds that mimic peptide substrates of the hepatitis C viral protease and inhibit the viral protease, more particularly as inhibitors of the NS3 serine protease from hepatitis C virus. Methods for synthesis of the compounds are also provided. The compounds find utility as antiviral agents directed at hepatitis C. The invention further provides methods of employing such inhibitors, alone or in combination with other therapeutic agents, to treat hepatitis C infection in a subject in need of such treatment.

La présente invention concerne de nouveaux composés macrocycliques imitant les substrats peptidiques de la protéase du virus de l'hépatite C et inhibant cette protéase virale. Plus particulièrement, ces composés sont utilisés comme inhibiteurs de la sérine protéase NS3 issue du virus de l'hépatite C. L'invention concerne également des procédés de synthèse de ces composés. Lesdits composés trouvent une utilité comme agents antiviraux dirigés contre l'hépatite C. L'invention concerne également des méthodes d'utilisation de ces inhibiteurs, seuls ou en combinaison avec d'autres agents thérapeutiques, pour traiter une infection par le virus de l'hépatite C chez un patient nécessitant un tel traitement.

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