C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/407 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/501 (2006.01) A61P 31/14 (2006.01)
Patent
CA 2515216
The present invention relates to compounds of Formula I, II or III, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: (I), (II), (III), wherein W is a substituted or unsubstituted heterocyclic ring system. The compounds inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
L'invention concerne des composés de la formule I, II ou III, ou un sel, un ester ou un promédicament pharmaceutiquement acceptable de ceux-ci, dans laquelle W représente un système de noyau hétérocyclique substitué ou non substitué. Ces composés inhibent l'activité de la sérine protéase, en particulier celle de la protéase du virus de l'hépatite C (VHC) NS3-NS4A. En conséquence, ces composés, qui interfèrent avec le cycle de vie du virus de l'hépatite C, sont également utiles en tant qu'antiviraux. L'invention concerne également des compositions pharmaceutiques comprenant les composés précités à administrer au patient souffrant d'une infection du VHC. L'invention concerne en outre des procédés de traitement d'une infection du VHC chez un patient par administration d'une composition pharmaceutique comprenant lesdits composés.
Miao Zenwei
Nakajima Suanne
Or Yat Sun
Sun Ying
Wang Zhe
Enanta Pharmaceuticals Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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