Macrocyclic heterocyclic aspartyl protease inhibitors

Details Macrocyclic heterocyclic aspartyl protease inhibitors Macrocyclic heterocyclic aspartyl protease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/08 (2006.01) A61K 31/395 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01)

Patent

CA 2609562

ABSTRACT Disclosed are compounds of the formula I (Chemical formula should be inserted here as it appears on abstract in final form) or a stereoisomer, tautomer, or pharmaceutically acceptable salt, solvate or ester thereof, wherein U, W, X, L, Y, M, Z, c, d, e, f, g, h, s, t, R1, R2, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16 , R17 and R18 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.

L'invention concerne des composés de formule I ou un stéréoisomère, un tautomère, ou un sel pharmaceutiquement acceptable, un solvate ou un ester desdits composés, formule dans laquelle U, W, X, L, Y, M, Z, c, d, e, f, g, h, s, t, R1, R2, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17 et R18 sont tels que définis dans la spécification, ainsi que des compositions pharmaceutiques comprenant les composés de formule I. L'invention concerne également une méthode d'inhibition de l'aspartyl protéase et, en particulier, des méthodes de traitement de maladies cardio-vasculaires, cognitives et neurodégénératives. Ladite invention se rapporte en outre à des méthodes de traitement de maladies cognitives ou neurodégénératives utilisant les composés de formule I en combinaison avec un inhibiteur de la cholinestérase ou un antagoniste m2 ou un agoniste m1 muscarinique.

Affiliated with

Also associated with

Rating

Macrocyclic heterocyclic aspartyl protease inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Macrocyclic heterocyclic aspartyl protease inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Macrocyclic heterocyclic aspartyl protease inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1841506