Macrocyclic indole derivatives for the treatment of...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 513/16 (2006.01) A61K 31/407 (2006.01) A61P 31/12 (2006.01) C07D 515/16 (2006.01)

Patent

CA 2693533

A class of macrocyclic compounds of formula (I), wherein R7, R9, B, F, M, Q, W, Y and Z are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV)NS3 protease, are provided. Also provided are processes for the synthesis and use of such 5 macrocyclic compounds for treating or preventing HCV infection.

L'invention porte sur une classe de composés macrocycliques représentés par la formule (I), dans laquelle R7, R9, B, F, M, Q, W, Y et Z sont tels que définis présentement, qui sont utiles comme inhibiteurs de protéases virales, en particulier la protéase NS3 du virus de l'hépatite C (VHC). L'invention porte également sur des procédés pour la synthèse et l'utilisation de tels composés macrocycliques pour le traitement ou la prévention de l'infection par le VHC.

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