Macrocyclic indole derivatives useful as hepatitis c virus...

Details Macrocyclic indole derivatives useful as hepatitis c virus... Macrocyclic indole derivatives useful as hepatitis c virus...

C - Chemistry, Metallurgy

07

D

C07D 515/08 (2006.01) A61K 31/407 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2733762

Inhibitors of HCV replication of formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein Y, R1, R2, R4 and n have the meaning defined in the claims. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use in HCV therapy.

La présente invention concerne des inhibiteurs de la réplication du virus de l'hépatite C de formule (I) comprenant des formes stéréochimiquement isomères et des sels, des hydrates, des solvates de ceux-ci, formule dans laquelle Y, R1, R2, R4 et n ont les significations définies dans les revendications. La présente invention concerne également des procédés de préparation desdits composés, les compositions pharmaceutiques les contenant et leur utilisation dans la thérapie contre le virus de l'hépatite C.

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