Macrocyclic inhibitors of hepatitis c virus ns3 serine protease

Details Macrocyclic inhibitors of hepatitis c virus ns3 serine protease Macrocyclic inhibitors of hepatitis c virus ns3 serine protease

C - Chemistry, Metallurgy

07

K

C07K 5/12 (2006.01) A61K 38/12 (2006.01) C07D 245/00 (2006.01)

Patent

CA 2540031

The present invention discloses novel compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease. The novel compounds typically include a 15-20 member macrocycle and have the general structure of structural Formula (1): wherein Z', L', M', R1, X and D are defined herein.

La présente invention a trait à de nouveaux composés présentant une activité inhibitrice de la protéase du virus de l'hépatite C ainsi qu'à des compositions pharmaceutiques comportant de tels composés et à leurs procédés d'utilisation pour le traitement de troubles associés à la protéase du virus de l'hépatite C. Les nouveaux composés comportent, de manière caractéristique, un macrocycle de 15 à 20 chaînons et ont une structure générale de formule (1), dans laquelle Z', L', M', R¿1?, X et D sont tels que définis dans la description.

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