C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 245/02 (2006.01) A61K 31/33 (2006.01) A61P 25/00 (2006.01) C07D 255/02 (2006.01) C07D 281/00 (2006.01)
Patent
CA 2544751
The present invention relates to novel macrocyclic compounds of the formula (I) wherein R1, R2, R3, U, V, W, X, Y, Z and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as pharmaceuticals and to pharma~ceutical compositions comprising them.
La présente invention concerne des composés macrocycliques correspondant à la formule (I) dans laquelle R¿1?, R¿2?, R¿3?, U, V, W, X, Y, Z et n sont définis dans la spécification, le nombre des atomes de noyau compris dans l'anneau macrocyclique étant de 14, 15, 16 ou 17, sous forme de base libre ou de sel d'addition acide; elle concerne leur préparation, leur utilisation en tant que pharmaceutiques et des compositions pharmaceutiques les comprenant.
Auberson Yves
Betschart Claudia
Glatthar Ralf
Laumen Kurt
Machauer Rainer
Fetherstonhaugh & Co.
Novartis Ag
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