Macrocyclic lactone combination compositions, vaccines and...

A - Human Necessities – 61 – K

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A61K 39/215 (2006.01) A61K 31/335 (2006.01) A61K 31/365 (2006.01) A61K 39/15 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2758276

An injectable composition, capable of preventing or controlling parasitic, viral, or bacterial infections or diseases, for example scours, in pregnant cows and viral infections or diseases in neonatal calves by parenterally administering to each cow in a herd of pregnant cows, a dose of a combination composition comprising: (a) at least one inactivated viral component derived from rotavirus and/or coronavirus; (b) a macrocyclic lactone active compound; and (c) a pharmaceutically acceptable parenteral carrier and preservative. The injectable compositions which include eprinomectin result in extremely low milk residues.

Cette invention concerne une composition injectable, capable de prévenir ou de lutter contre les infections ou les maladies parasitaires, virales, ou bactériennes, par exemple, diarrhées chez la vache gravide et les infections ou les maladies virales néonatales chez le veau par administration par voie parentérale à chaque vache d'un troupeau de vaches gravides d'une dose d'une composition combinée comprenant : (a) au moins un composant viral inactivé dérivé d'un rotavirus et/ou d'un coronavirus ; (b) un principe actif de lactone macrocyclique ; et (c) un véhicule à usage parentéral et un conservateur pharmaceutiquement acceptables. Les compositions injectables selon l'invention qui comprennent de l'éprinomectine donnent des résidus de lait extrêmement bas.

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