C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 257/02 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 49/08 (2006.01) A61K 49/14 (2006.01) C07D 403/12 (2006.01) C07F 5/00 (2006.01)
Patent
CA 2453106
The invention relates to macrocyclic metal complexes and production and use thereof for production of conjugates with biomolecules. The conjugates are suitable as contrast agents in NMR and radio diagnostics and for radiotherapy. According to the invention, a high relaxivity and a fine-tuning of the relaxivity may be achieved by means of a special ligand formation with the macrocycles.
L'invention concerne des complexes métalliques macrocycliques, ainsi que leur production et leur utilisation pour la préparation de composés conjugués avec des biomolécules. Les composés conjugués sont utilisés comme agents de contraste dans le diagnostic RMN et le diagnostic radio ainsi qu'en radiothérapie. Grâce à une formation spéciale de ligands des macrocycles, on obtient une relaxivité élevée et une adaptation fine de la relaxivité.
Bauer Hans
Frenzel Thomas
Michl Gunther
Platzek Johannes
Raduchel Bernd
Marks & Clerk
Schering Ag
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