Macrocyclic oximyl hepatitis c protease inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 487/04 (2006.01) A61K 31/395 (2006.01) A61K 31/407 (2006.01) A61P 31/14 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2653034

The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

La présente invention concerne des composés répondant à la formule I, ou des sels, des esters, ou des promédicaments pharmaceutiquement acceptables de ces composés : qui inhibent l'activité de la sérine protéase, en particulier l'activité de la protéase NS3-NS4A du virus de l'hépatite C (VHC). Par conséquent, les composés selon la présente invention interfèrent avec le cycle de vie du virus de l'hépatite C et ils se révèlent utiles comme agents antiviraux. La présente invention concerne en outre des compositions pharmaceutiques qui contiennent les composés susmentionnés et sont destinées à être administrées à un sujet souffrant d'une infection par le VHC. L'invention concerne également des procédés de traitement d'une infection VHC chez un sujet grâce à l'administration d'une composition pharmaceutique contenant les composés de la présente invention.

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