Macrocyclic oximyl hepatitis c serine protease inhibitors

Details Macrocyclic oximyl hepatitis c serine protease inhibitors Macrocyclic oximyl hepatitis c serine protease inhibitors

C - Chemistry, Metallurgy

07

K

C07K 5/087 (2006.01) A61K 38/06 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2709089

The present invention relates to compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for admin-istration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising a compound of the present invention.

La présente invention concerne des composés de formule (I), ou leurs sels, esters ou promédicaments pharmaceutiquement acceptables, se révélant capables d'inhiber l'activité des protéases à sérine et, en particulier, de la protéase NS3-NS4A du virus de l'hépatite C (VHC). En conséquence, les composés de la présente invention interfèrent avec le cycle de vie du virus de l'hépatite C et se révèlent également utiles en tant qu'agents antiviraux. La présente invention concerne, en outre, des compositions pharmaceutiques comprenant les composés susmentionnés en vue de leur administration à un sujet souffrant d'une infection à VHC. L'invention concerne encore des procédés de traitement d'une infection à VHC chez un sujet, procédés impliquant l'administration audit sujet d'une composition pharmaceutique comprenant un composé de la présente invention.

Affiliated with

Also associated with

Rating

Macrocyclic oximyl hepatitis c serine protease inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Macrocyclic oximyl hepatitis c serine protease inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Macrocyclic oximyl hepatitis c serine protease inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1409636