Macrocyclic peptides active against the hepatitis c virus

Details Macrocyclic peptides active against the hepatitis c virus Macrocyclic peptides active against the hepatitis c virus

C - Chemistry, Metallurgy

07

K

C07K 5/08 (2006.01) A61K 38/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2498572

Compounds of formula (I): wherein R1 is (C1-8)alkyl, (C3-7)cycloalkyl, {(C1- 6)alkyl-(C3-7)cycloalkyl} or Het, which are all optionally substituted from 1 to 3 times with halo, cyano, nitro, O-(C1-6)alkyl, amido, amino or phenyl, or R1 is C6 or C10 aryl which is optionally substituted from 1 to 3 times with halo, cyano, nitro, (C1-6)alkyl, O-(C1-6)alkyl, amido, amino or phenyl; or a pharmaceutically acceptable salt thereof, useful as an inhibitor of the HCV NS3 protease.

La présente invention concerne des composés représentés par la formule (I) dans laquelle R?1¿ représente alkyle (C¿1-8?), cycloalkyle (C¿3-7?), {alkyle (C¿1-6?)-cycloalkyle (C¿3-7?)} ou Het, qui, tous, sont facultativement substitués entre 1 et 3 fois par halo, cyano, nitro, O-alkyle (C¿1-6?), amido, amino ou phényle, ou bien R?1¿ représente aryle C¿6? ou C¿10? qui est facultativement substitué entre 1 et 3 fois par halo, cyano, nitro, alkyle (C¿1-6?), O-alkyle (C¿1-6?), amido, amino ou phényle. Ces composés ou un sel pharmaceutiquement acceptable de ces derniers sont utiles en tant qu'inhibiteur de la protéase NS3 VHC. Formule (I)

Affiliated with

Also associated with

Rating

Macrocyclic peptides active against the hepatitis c virus does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Macrocyclic peptides active against the hepatitis c virus, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Macrocyclic peptides active against the hepatitis c virus will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1492251