C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 2/00 (2006.01) A61K 49/00 (2006.01) A61K 49/08 (2006.01) A61K 51/06 (2006.01) C08F 8/00 (2006.01) C08G 69/02 (2006.01)
Patent
CA 2068266
Abstract of the Disclosure Polymeric compounds of general formula I . (M)nA (I), in which M stands for the radical of a macrocyclic complexing agent, A stands for a backbone molecule, which shows a deficit of n amino groups, n hydroxy groups or n carboxy groups, n stands for the numbers 1 to 400, characterized in that M, independent of one another, stands for complexing agents of general formula IA Image (IA), in which D, E, G, K, can be the same or different, each stand for the group -(CH2)o- with o meaning the numbers 2, 3, 4 or 5 q stands for the numbers 0, 1 or 2, R1 stands for a hydrogen atom, a branched or unbranched C1-C4 alkyl, phenyl, C7-C12 aralkyl group, U stands for a CO2H or PO3H2 group, Z stands for a straight-chain, branched, saturated or un- saturated C1-C20 alkylene group optionally containing imino, phenylene, phenylenoxy, phenylenimino, amide, hydrazide, car- bonyl, ester group or groups, oxygen, sulfur and/or nitrogen atom or atoms, optionally substituted by hydroxy, mercapto, oxo, thioxo, carboxy, ester and/or amino group or groups, X stands for a -CONH-, -NHCO-, -NHCS-, -NHCSNH-, -NHCONH-, -CO2-, -O-, -OCO-, -COCH20-, -NR2CH2CONH-, -NR2CH2COO-, -OCHR2CONH-, -OCHR2COO-, and R2 stands for a hydrogen atom or the group -(CH2)pCOOH with p meaning the numbers 1-5, and for an -NR group, in which R means a hydrogen atom, a C1-C20 hydrocarbon radical optionally substituted by 1 to 3 carboxy acids, 1 to 3 sulfonic acids, 1 to 5 hydroxy, 1 to 5 C1-C10 alkoxy, 1 to 5 C6-C10 aryloxy, 1 to 5 C7-C11 aralkoxy, 1 to 5 ester, 1 to 5 amide groups and/or optionally containing 1 to 3 carbonyl, 1 to 3 ester, 1 to 3 amide, 1 sulfonyl group, 1 to 10 oxygen atoms, 1 to 4 nitrogen atoms, or a second molecule IA, which does not have to be identical with the first, their completely or incompletely metalated complexes with the elements of atomic numbers 21-29, 31, 32, 37-39, 42-44, 49, 57-83 as well as their salts, are valuable pharmaceutical agents.
Frenzel Thomas
Gries Heinz
Platzek Johannes
Schmitt-Willich Heribert
Schuhmann-Giampieri Gabriele
Marks & Clerk
Schering Aktiengesellschaft
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