Macrocyclic pyrimidines as protein kinase inhibitors

Details Macrocyclic pyrimidines as protein kinase inhibitors Macrocyclic pyrimidines as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 513/08 (2006.01) A61K 31/529 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 239/42 (2006.01) C07D 295/096 (2006.01) C07D 487/08 (2006.01) C07D 487/18 (2006.01) C07D 498/08 (2006.01) C07D 498/18 (2006.01) C07D 513/18 (2006.01) C07D 515/08 (2006.01)

Patent

CA 2735420

Macrocyclic derivative compounds that inhibit protein kinase enzymes are disclosed along with pharmaceutical compositions comprising these compounds and methods for synthesizing the same. Such compounds have utility in the treatment of proliferative diseases resulting from unregulated and/or disturbed kinase activity such as cancers, psoriasis, viral and bacterial infections, inflammatory and autoimmune diseases.

L'invention porte sur des composés dérivés macrocycliques qui inhibent les enzymes protéines kinases ainsi que sur des compositions pharmaceutiques comprenant ces composés et des procédés de synthèse de ceux-ci. De tels composés ont une utilité dans le traitement de maladies prolifératives résultant d'une activité kinase non régulée et/ou troublée telle que des cancers, le psoriasis, des infections virales et bactériennes, des maladies inflammatoires et auto-immunes.

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