Macrocyclic pyrimidines, the production thereof and the use...

Details Macrocyclic pyrimidines, the production thereof and the use... Macrocyclic pyrimidines, the production thereof and the use...

C - Chemistry, Metallurgy

07

D

C07D 513/08 (2006.01) A61K 31/529 (2006.01) A61P 35/00 (2006.01) C07D 239/42 (2006.01) C07D 239/48 (2006.01) C07D 409/12 (2006.01) C07D 487/08 (2006.01) C07D 498/08 (2006.01) C07D 513/18 (2006.01) C07D 515/08 (2006.01)

Patent

CA 2492319

The invention relates to macrocyclic pyrimidine derivatives of general formula (I) -wherein R1 to R5, X, Y, A, B, m and n have the designations cited in the description - as inhibitors of the cyclin-dependent kinase. The invention also relates to methods for producing said derivatives and to the use of the same as medicaments for treating various illnesses.

L'invention concerne des dérivés de pyrimidines macrocycliques de formule générale (I), dans laquelle R?1¿ à R?5¿, X, Y, A, B, m et n ont la signification indiquée dans la description, lesdits dérivés servant d'inhibiteurs de la kinase cycline-dépendante. L'invention concerne également leur production et leur utilisation comme médicament pour le traitement de différentes maladies.

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