Macrocyclic serine protease inhibitors

Details Macrocyclic serine protease inhibitors Macrocyclic serine protease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4709 (2006.01) A61P 31/14 (2006.01) C07D 213/68 (2006.01) C07D 215/233 (2006.01) C07D 239/34 (2006.01) C07D 239/88 (2006.01) C07D 277/22 (2006.01) C07D 417/14 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2758072

Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula Ia or Ib, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.

Cette invention concerne des inhibiteurs macrocycliques de la sérine protéase, par exemple de formule Ia ou Ib, des compositions pharmaceutiques comprenant ces composés, et leurs procédés de préparation. L'invention concerne également des méthodes d'utilisation de ces composés dans le traitement de l'infection par le virus de l'hépatite C (VHC) chez un hôte.

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