C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 267/00 (2006.01) A61K 31/335 (2006.01) A61K 31/395 (2006.01) A61P 25/28 (2006.01) C07D 273/01 (2006.01) C07D 313/00 (2006.01) C07D 321/00 (2006.01) C07D 323/00 (2006.01) C07D 413/04 (2006.01)
Patent
CA 2587083
The present invention is directed to macrocyclic tertiary amine compounds represented by general formula (I), which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta- secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
L'invention concerne des composés formés d'amines tertiaires macrocycliques de formule générale (I), qui sont des inhibiteurs de l'enzyme bêta-sécrétase et qui sont utiles dans le traitement de maladies dans lesquelles l'enzyme bêta-sécrétase est impliquée, notamment la maladie d'Alzheimer. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés et l'utilisation de ceux-ci et desdites compositions dans le traitement des maladies dans lesquelles l'enzyme bêta-sécrétase est impliquée.
Lindsley Stacey
Moore Keith P.
Nantermet Philippe G.
Rajapakse Hemaka A.
Selnick Harold G.
Merck & Co. Inc.
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
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