Macrolactone derivatives

Details Macrolactone derivatives Macrolactone derivatives

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) A61K 31/395 (2006.01) A61P 31/10 (2006.01)

Patent

CA 2692260

The present invention relates to a compound of the formula (I), where X and Y independently of one another are OH, O-(C1-C6)-alkyl, NH2 or NH-(C1-C6)-alkyl, or X and Y together form a group -O-, R1 and R2 independently of one another are Cl or H, R3 is H, (C1-C6)-alkyl, C(=O)-(C1-C6)-alkyl or (C1-C6)-alkylene-NH-(C1-C6)-alkyl, and R4 is H, (C1-C6)-alkyl or C(=O)-(C1-C6)-alkyl, or a physiologically acceptable salt thereof, which is formed by the microorganism ST 201196 (DSM 18870), use thereof for the treatment and/or prophylaxis of fungal disorders, medicaments containing a compound of the formula (I), processes for production thereof and the microorganism ST 201196 (DSM 18870). The present invention relates to a compound of the formula (I), where X and Y independently of one another are OH, O-(C1-C6)-alkyl, NH2 or NH-(C1-C6)-alkyl, or X and Y together form a group -O-, R1 and R2 independently of one another are Cl or H, R3 is H, (C1-C6)-alkyl, C(=O)-(C1-C6)-alkyl or (C1-C6)-alkylene-NH-(C1-C6)-alkyl, and R4 is H, (C1-C6)-alkyl or C(=O)-(C1-C6)-alkyl, or a physiologically acceptable salt thereof, which is formed by the microorganism ST 201196 (DSM 18870), use thereof for the treatment and/or prophylaxis of fungal disorders, medicaments containing a compound of the formula (I), processes for production thereof and the microorganism ST 201196 (DSM 18870).

La présente invention concerne un composé de formule (I), dans laquelle X et Y représentent indépendamment l'un de l'autre OH, O-(C1-C6)-alkyle, NH2 ou NH-(C1-C6)-alkyle ou X et Y forment ensemble un groupement -O-, R1 et R2 représentent indépendamment l'un de l'autre Cl ou H, R3 représente H, (C1-C6)-alkyle, C(=O)-(C1-C6)-alkyle ou (C1-C6)-alkylène-NH-(C1-C6)-alkyle et R4 représente H, (C1-C6)-alkyle ou C(=O)-(C1-C6)-alkyle, ou un de ses sels physiologiquement acceptables qui est formé à partir du microorganisme ST 201196 (DSM 18870). L'invention concerne également l'utilisation du composé de formule (I) pour le traitement et/ou la prophylaxie d'acromycoses, des médicaments contenant un composé de formule (I), leurs procédés de fabrication et le microorganisme ST 201196 (DSM 18870).

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