Macrolide compounds

C - Chemistry – Metallurgy – 12 – P

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C12P 17/18 (2006.01) A01N 43/32 (2006.01) A01N 43/90 (2006.01) A61K 31/365 (2006.01) C07D 493/22 (2006.01) C07H 19/01 (2006.01)

Patent

CA 1318629

ABSTRACT MACROLIDE COMPOUNDS Compounds of formula (1) Image (1) and salts thereof, wherein R1 represents a methyl, ethyl or isopropyl group; Y1 is -CH2-, Y2 is -CH- and X represents Image [where R2 represents a hydrogen atom or a group OR8 (where OR8 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms) and R3 represents a hydrogen atom, or R2 and R3 together with the carbon atom to which they are attached represent >C=O, >C=CH2 or >C=NOR9 (where R9 represents a hydrogen atom, a C1-8 alkyl group or a C3-8 alkenyl group) and the group >C=NOR9 is in the E configuration] or -Y1-X-Y2 - represents -CH=CH-CH- or -CH2-CH=C-; R4 represents a group OR8 as defined above and R5 represents a hydrogen atom, or R4 and R5 together with ths carbon atom to which they are attached represent >C=O or >C=NOR9a (where R9a is as defined above for R9); R6 represents a hydrogen atom and R represents -CH2OH, -CHO, -CO2H or a carboxylic acid ester or amide group; or R6 represents a hydroxyl group and R represents a methyl group; and R7 represents a hydrogen atom or when R represents a group -CH2OH then R7 may also represent a hydroxyl group. The compounds may be used to control nematode, acarine, insect or other pests.

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