Macrolide compounds

C - Chemistry – Metallurgy – 12 – P

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167/185, 167/202

C12P 17/18 (2006.01) A01N 43/90 (2006.01) A61K 31/365 (2006.01) C07D 493/22 (2006.01) C07H 19/01 (2006.01)

Patent

CA 1321965

ABSTRACT MACROLIDE COMPOUNDS Compounds of formula (1) Image (1) wherein R represents a sugar residue or an acylated derivative thereof; R1 represents a methyl, ethyl or isopropyl group; Y is -CH2, Y2 is -CH- and X represents Image (wherein R2 represents a hydrogen atom or a group OR6 (where OR6 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms) and R3 represents a hydrogen atom, or R2 and R3 together with the carbon atom to which they are attached represent >C=0, >C=CH2 or >C=NOR7 (where R7 represents a hydrogen atom, a C1-8 alkyl group or a C3-8 alkenyl group) and the group >C=NOR7 is in the E configuration] or -Y1-X-Y2- represents -CH=CH-CH- or -CH2-CH=C- ; and R4 represents a group OR6 as defined above and R5 represents a hydrogen atom, or R4 and R5 together with the carbon atom to which the are attached represent >?=0 or >C=NOR8 (where R8 is as defined above for R7), and salts thereof. The compounds may be used to control nematode, acarine, insect or other pests.

599087

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