Macrolide-conjugates with anti-inflammatory activity

Details Macrolide-conjugates with anti-inflammatory activity Macrolide-conjugates with anti-inflammatory activity

C - Chemistry, Metallurgy

07

J

C07J 1/00 (2006.01) C07D 273/00 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2523081

The present invention relates to new compounds represented by Formula (I); wherein M represents a macrolide subunit of the substructure II, Formula (II); L represents the chain of the substructure III, Formula (III); D represents the steroid or nonsteroidal subunit derived from steroid or nonsteroidal (NSAID) drugs with anti-inflammatory activity. The present invention relates also to pharmaceutically acceptable salts and solvates of such prepared compounds, to processe and intermediates for their preparation, as well as to the improved therapeutic action and the use in the treatment of inflammatory diseases and conditions in humans and animals.

La présente invention se rapporte à de nouveaux composés répondant à la formula (I), dans laquelle M représente une sous-unité macrolide ayant la sous-structure (II), L représente la chaîne de la sous-structure (III), et D représente la sous-unité stéroïdienne ou non stéroïdienne dérivée de médicaments stéroïdiens ou non stéroïdiens à activité anti-inflammatoire (NSAID). La présente invention se rapporte également à des sels et solvates pharmaceutiquement acceptables de ces composés préparés, à des procédés et intermédiaires permettant leur préparation, ainsi qu'à l'action thérapeutique améliorée, et son application au traitement des pathologies et affections inflammatoires chez l'homme et les animaux.

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