Macrolides for the treatment of reversible obstructive...

Details Macrolides for the treatment of reversible obstructive... Macrolides for the treatment of reversible obstructive...

A - Human Necessities

61

K

A61K 31/40 (2006.01) A61K 31/445 (2006.01)

Patent

CA 2054203

Compounds of formula (I), wherein R1 and R2 together represent two vicinal hydrogen atoms, or form a second bond between the vicinal carbon atoms to which they are attached; R3 represents H, OH, alkoxy or protected hydroxy; R4 repres- ents OH; R5 represents H, alkyl or alkenyl; R6 and R7 independently represent O, (H,OH), (H,protected hydroxy) or (H,al- koxy); X and Y independently represent O, (H,OH) or (H,H); n is 1 or 2; or pharmaceutically acceptable derivatives there- of; are provided for the treatment of reversible obstructive airways disease, particularly asthma. Compositions containing such compounds are also disclosed.

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