Macrolides with antitumor activity

Details Macrolides with antitumor activity Macrolides with antitumor activity

C - Chemistry, Metallurgy

07

D

C07D 493/20 (2006.01) A61K 31/365 (2006.01) A61K 31/7048 (2006.01) A61P 35/00 (2006.01) C07H 19/01 (2006.01) C12N 1/20 (2006.01) C12P 17/18 (2006.01) C12P 19/62 (2006.01)

Patent

CA 2299269

The compound referred to herein as IB-96212, having structure (I) can be obtained by cultivating strain the Micromonospora sp. ES25-008, available under the accession number CECT-3333, and can be hydrolysed to give IB-96212B having structure (II). The sugar substituent which is L-rhodinose can itself be derivatised or the sugar can be replaced, in either case giving further derivatives of IB-96212 having a group other than L-rhodinose at the position of the sugar.

Pour obtenir le composé appelé dans cette invention IB-96212 correspondant à la structure (I) on cultive la souche de Micromonospora sp. ES25-008, disponible sous le numéro d'enregistrement CECT-3333; et on peut l'hydrolyser pour obtenir IB-96212B correspondant à la structure (II). Le substituent sucre qui est L-rhodinose peut lui-même être dérivé ou bien le sucre peut être remplacé, dans tous les cas ceux-ci donnant des dérivés de IB-96212 comportant un groupe autre que L-rhodinose à la position du sucre.

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