Macromer-melt formulations

A - Human Necessities – 61 – K

Patent

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A61K 31/74 (2006.01)

Patent

CA 2585024

The invention provides methods and articles for the administration of a biologically active substance (BAS). These methods and articles provide for the controlled and sustained delivery of relatively large quantities of these substances with a low burst effect. The articles made using the method of the invention have increased percentages (w/w) of macromer, increased crosslinking density, and reduced pore size in comparison to articles made using solution methods.

Procédés et articles pour l'administration d'une substance biologiquement active (BAS). Ces procédés et articles permettent la libération régulée et prolongée de quantités relativement importantes de ces substances, avec un faible effet de décharge. Les articles fabriqués sur la base des procédés selon la présente invention possèdent des pourcentages (en poids) accrus de macromère, une densité du réseau accrue et une taille réduite des pores par comparaison aux articles fabriqués selon des procédés reposant sur l'utilisation de solutions.

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