Macromolecular contrast media for mr imaging

Details Macromolecular contrast media for mr imaging Macromolecular contrast media for mr imaging

C - Chemistry, Metallurgy

08

G

C08G 69/48 (2006.01) A61K 49/00 (2006.01) A61K 49/08 (2006.01) C08B 15/00 (2006.01) C08B 31/00 (2006.01) C08B 37/02 (2006.01) G01R 33/28 (2006.01)

Patent

CA 2163232

A macromolecular contrast agent for magnetic resonance imaging of the vascular system is constructed of a polymeric backbone structure with a plurality of spacer arms bonded to the backbone structure, each spacer arm terminating in at least one paramagnetic complex. The polymeric backbone thus serves as an amplifier by supporting a multitude of paramagnetic complexes, and the spacer arms contribute to the molecular weight. The spacer arms further contribute useful properties to the agent, such as hydrophilicity and the ability to cleave at a relatively rapid rate in blood.

Un agent de contraste macromoléculaire s'utilisant en imagerie par résonance magnétique du système vasculaire est constitué par une structure de squelette polymère comportant une pluralité de bras d'espacement liés à ladite structure, chacun desdits bras se terminant en au moins un complexe paramagnétique. De ce fait, le squelette polymère sert d'amplificateur étant donné qu'il supporte une multitude de complexes paramagnétiques et les bras d'espacement contribuent au poids moléculaire. Les bras d'espacement confèrent, de plus, des propriétés efficaces à l'agent, telles qu'une caractéristique hydrophile, ainsi qu'une aptitude au clivage à une vitesse relativement rapide dans le sang.

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