Macromolecular delivery systems for non-invasive imaging,...

Details Macromolecular delivery systems for non-invasive imaging,... Macromolecular delivery systems for non-invasive imaging,...

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61F 2/00 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/48 (2006.01) A61K 9/52 (2006.01) A61K 9/66 (2006.01) A61K 9/70 (2006.01)

Patent

CA 2557448

This invention relates to biotechnology, more particularly, to water-soluble polymeric delivery systems for the imaging, evaluation and/or treatment of rheumatoid arthritis and other inflammatory diseases. Using modern MR imaging techniques, the specific accumulation of macromolecules in arthritic joints in adjuvant-induced arthritis in rats is demonstrated. The strong correlation between the uptake and retention of the MR contrast agent labeled polymer with histopathological features of inflammation and local tissue damage demonstrates the practical applications of the macromolecular delivery system of the invention.

L'invention concerne la biotechnologie, plus particulièrement des systèmes d'administration polymères hydrosolubles destinés à l'imagerie, à l'évaluation et/ou au traitement de la polyarthrite rhumatoïde et autres maladies inflammatoires. A l'aide des techniques d'imagerie par résonance magnétique modernes, on a démontré l'accumulation spécifique de macromolécules dans des articulations arthritiques chez des rats atteints d'arthrite induite par un adjuvant. La forte corrélation entre l'absorption ainsi que la rétention du polymère marqué à l'aide de l'agent de contraste RM et les caractéristiques histopathologiques d'inflammation et de lésions des tissus locales démontre qu'il existe des possibilités d'applications pratiques du système d'administration macromoléculaire selon l'invention.

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