Macromolecular drug complexes and compositions containing...

A - Human Necessities – 61 – K

Patent

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A61K 9/107 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2409268

Macromolecular drug complexes containing a drug, like human growth hormone, and a polymer having a plurality of acid moieties, like carboxyl moieties or phosphonic acid moieties, and compositions containing the same, are disclosed. Compositions, particularly microemulsions, containing the macromolecular complexes are administered to individuals suffering from a disease or condition, and the complexes release the drug, in vivo), to treat the disease or condition, and to reduce, eliminate, or reverse complications associated with the disease.

L'invention concerne des complexes de médicaments macromoléculaires contenant un médicament tel que l'hormone de croissance humaine, et un polymère comprenant une pluralité de groupes fonctionnels acides, par exemple des groupes carboxyle ou des groupes acide phosphonique, ainsi que des compositions contenant ces complexes. Des compositions, en particulier des microémulsions contenant ces complexes macromoléculaires, sont administrées à des individus présentant une maladie ou un trouble, et ces complexes libèrent le médicament in vivo afin de traiter la maladie ou le trouble et de réduire, de supprimer ou de faire régresser les complications associées à la maladie.

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