Macromolecular microparticles and methods of production

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 11/08 (2006.01) A61K 9/16 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/06 (2006.01) C07H 21/00 (2006.01) C07K 17/08 (2006.01) C08B 37/00 (2006.01) G01N 33/543 (2006.01) G01N 33/544 (2006.01)

Patent

CA 2157793

A macromolecular microparticle composition formed by dehydrating an aqueous macromolecule solution and crosslinking the dehydrated macromolecules with a crosslinking agent while in a liquid phase or with heat. Preferably, the dehydrating agent is a polymer mixture of polyvinylpyrrolidone and polyethylene glycol, the crosslinking reagent is glutaraldehyde, and the macromolecule is a protein, most preferably an immunoglobulin. Methods of use for research, diagnostics and therapeutics are also provided.

On prépare une composition de microparticules macromoléculaires par déshydratation d'une solution aqueuse de macromolécules et par réticulation des macromolécules déshydratées avec un agent de réticulation pendant une phase liquide ou avec de la chaleur. De préférence, l'agent de déshydratation est un mélange polymère de polyvinylpyrrolidone et de polyéthylène glycol, le réacteur de réticulation est glutaraldéhyde et la macromolécule est une protéine, de préférence, une immunoglobuline. L'invention concerne également des procédés d'utilisation dans une optique expérimentale, diagnostique et thérapeutique.

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