Macromolecular structures for boron neutron-capture therapy

Details Macromolecular structures for boron neutron-capture therapy Macromolecular structures for boron neutron-capture therapy

C - Chemistry, Metallurgy

07

F

C07F 9/547 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01) C07B 59/00 (2006.01) C07F 9/12 (2006.01) C07F 9/6596 (2006.01) C07H 19/04 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2135158

A general synthetic method has been developed for the rapid and efficient production of a variety of boron-rich macromolecules suitable for conjugation with of inclusion in receptor-mediated delivery systems as well as other delivery systems. Preparation techniques have been developed to yield precisely ordered oligophosphates which are soluble, hydrophilic, may be homogenous, and may be prepared with a variety of functional groups.

Un nouveau procédé général de synthèse sert à produire rapidement et efficacement une variété de macromolécules riches en bore et capables de se conjuguer avec des systèmes d'administration thérapeutique activés par des récepteurs, ainsi qu'avec d'autres types de systèmes ou de s'insérer dans lesdits systèmes. De nouvelles techniques de préparation servent à produire des oligophosphates à orientation précise, qui sont solubles, hydrophiles et, éventuellement, homogènes, et qui peuvent se préparer avec une variété de groupes fonctionnels.

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